Etoricoxib

Etoricoxib

Etoricoxib is a generic drug manufactured by Merck & Co. and marketed under the Arcoxia brand in more than 70 countries around the world (including Algix brand in Italy, Eto in Bangladesh, and Nuvoxia in India). It has yet to be approved by the US FDA which requires further efficacy and heath safety data from the makers prior to being marketed in the US. Arcoxia tablets can be recognized by their white, light blue or green rounded triangular shape and are offered in 30 mg, 60 mg, 90 mg, and 120 mg Etoricoxib formulation. They are currently available from online drugstores in the UK with or without prescription.
Synonyms: Arcoxia

Indication

The drug is effectively an pain reliever and is indicated for treating the pain and inflammatory symptoms associated with ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, osteoarthritis, and gout attacks. It is also prescribed for relieving acute plain such as cramp-like discomforts prior to or while menstruating, chronic low back pain, and pain associated with dental treatment. But these indications may vary from country to country.

Mechanism of action

Etoricoxib belongs to a group of medicines called Coxibs or COX-2 inhibitors. It works similarly as most traditional anti-inflammatory drugs classified as NSAID (Non-Steroidal Anti-Inflammatory Drugs) by blocking the action or production of certain substances known to cause inflammation or pain. It inhibits isoform 2 produced in the COX-2 (cyclo-oxigenase) enzyme and reduces the production of PG (Prostaglandins) from archidonic acid. It selectively inhibits COX-2 more significantly than COX-1 enzymes that traditional NSAID non-selectively inhibits and accounts for its diminished sided effects in the gastrointestinal tract. In several clinical tests, the brand Arcoxia has shown fewer risks to side effects such as bleeding stomach ulcers) than using NSAIDs. However, it should be noted that its benefits are reversed when taking Aspirin with it.

Dosage

The drug is usually taken once daily with or without food and is based on the dosage prescribed by your doctor for treating different ailments. Certain existing health conditions or medical history will require different dosing which will also depend on age, gender and the use of any other drug that may interact with it. It is, therefore. important for you to consult with your doctor for the right dosing. When prescribed daily, it should be taken at the same time of day. Once you know the dosage and duration of treatment, you can buy 60mg or 90mg Etoricoxib in any UK online drugstores and get discounts for one-time volume orders to last you the entire treatment duration

.

Side effects

Etoricoxib drugs can make you feel drowsy, sleep or dizzy. Hence, do not drive or operate heavy machinery after taking it. Other side effects includes mild headache, nausea, dispepsia (indigestion), flu-like symptoms, heartburn and stomach discomfort, slight increase in blood pressure, irregular heart palpitation, and swelling of legs and feet (Oedema). These side effects should recede shortly after taking the drug, but if any of them persist, consult with your doctor or pharmacist immediately. Some infrequent but serious side effects include jaundice (yellowing of skin and eyes) indicating liver problem, chest pains, shortness of breath, and severe or prolonged bowel discomforts or blackened stools. Seek immediate medical attention if any of these serious reactions appear.

Caution

Etoricoxib drugs should be taken with caution if you have an infection, have a history of stroke, ulcers or stomach bleeding, kidney or liver disease, heart attack or other cardiovascular ailments; are diabetic; dehydrated from prolonged vomiting or diarrhea; have high blood pressure, have high cholesterol, or have swelling due to fluid retention. Elderly patients (65 years and over) and those who smoke are likewise cautioned.

If you are taking Aspirin to relieve pain, or NSAIDs to relieve painful symptoms of inflammation, you are advised not to take Arcoxia or any Etoricoxib-based drugs. In addition, patients with known allergies to NSAIDs, COX-2 inhibitors as well as Aspirin are also better of not taking Etoricoxib. Pregnant or breast-feeding women and children below 16 years old should not take the drug. Patients suffering from uncontrolled hypertension, are diagnosed with inflammatory bowel disorders like ulcerative colitis and Crohn's disease, as well as patients with cardiovascular problems or have undergone bypass surgery should not take the drug. Consult with your doctor prior to taking Etoricoxib drugs even if these can be bought online without prescription.